# US 10,213,392 B2 · Pharmaceutical composition for use in medical and veterinary ophthalmology

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- Number: US 10,213,392 B2
- Document ID: US10213392B2
- Status: Granted
- Kind: B2
- Application number: 15/648,314
- Filed: 2017-07-12
- Published: 2017-10-26
- Granted: 2019-02-26
- Earliest claimed: 2009-06-10
- Assignees: Mitotech SA
- Applicants: Mitotech SA
- Inventors: Maxim V. Skulachev
- Web page: https://patentgrep.com/patent/US10213392B2

## CPC

- A61K 31/122: having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K 9/0048: {Eye, e.g. artificial tears}
- A61P 17/18: Antioxidants, e.g. antiradicals (preparations for protection against sunlight A61Q17/00)
- A61P 27/02: Ophthalmic agents
- A61P 27/06: Antiglaucoma agents or miotics
- A61P 27/12: for cataracts
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/04: Antibacterial agents
- A61P 31/12: Antivirals
- C09B 69/001: {Dyes containing an onium group attached to the dye skeleton via a bridge}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C09B: ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES {, e.g. PIGMENTS}; MORDANTS; LAKES (fermentation or enzyme using processes to synthesise a desired chemical compound C12P)

## Abstract

The invention relates to the manufacturing and use of pharmaceutical compositions of medicines (ophthalmic preparations) comprising a mitochondria-addressed antioxidant and a set of auxiliary substances providing effective treatment for ophthalmological diseases in humans and animals.

## Claims

### Claim 1

A method of treating an eye pathology, comprising administering to a subject afflicted with such an eye pathology a therapeutically-effective amount of a pharmaceutical composition comprising:
(a) from 1 nm to 25000 nm of a mitochondria-addressed antioxidant comprising:
(b) from 0.01% to 0.2% of a lipophilic, cationic concentration stabilizer that stabilizes a concentration of the mitochondria-addressed antioxidant by preventing reversible and irreversible absorption of the antioxidant to walls of a vial containing the pharmaceutical composition, the stabilizer comprising a benzalkonium salt, berberine, palmatine, tetraphenylphosphonium, tetrabutyl ammonium, or combinations thereof; and
(c) from 0.001% to 1% of a prolongator comprising a disaccharide, a trisaccharide, a polysaccharide, methylcellulose, hydroxyethylcellulose, hydroxypropyl-methyl cellulose, carboxymethylcellulose, sodium chondroitin sulfate, sodium hyaluronate, carboxyvinyl polymer, polyvinyl ethanol, polyvinylpyrrolidone, macrogol, or combinations thereof.

### Claim 2 (depends on 1)

The method of claim 1, wherein the eye pathology is macular degeneration of the retina.

### Claim 3 (depends on 1)

The method of claim 1, wherein the eye pathology is cataract, senile cataract and/or diabetic cataract.

### Claim 4 (depends on 1)

The method of claim 1, wherein the eye pathology is a retinopathy.

### Claim 5 (depends on 4)

The method of claim 4, wherein the retinopathy is retinal detachment, detached retinal vessels, detached choroid, optic nerve retinopathy, optic nerve atrophy, central and peripheral chorioretinal dystrophies, or uveitis.

### Claim 6 (depends on 1)

The method of claim 1, wherein the eye pathology is intraocular hemorrhage or traumatic hemorrhage.

### Claim 7 (depends on 1)

The method of claim 1, wherein the eye pathology is conjunctivitis, eye ulcer, keratitis, or dry keratoconjunctivitis.

### Claim 8 (depends on 1)

The method of claim 1, wherein the eye pathology is glaucoma.