US 10,209,335 B2Granted

Nuclear magnetic resonance (NMR) fingerprinting with singular value decomposition (SVD) compression

AssigneeCase Western Reserve University

InventorsMark Griswold, Debra McGivney, Dan Ma

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Abstract

Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic that repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals that are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The varying parameters may include flip angle, echo time, RF amplitude, and other parameters. The NMR apparatus may also include a signal logic that produces an NMR signal evolution from the NMR signals, and a characterization logic that characterizes a resonant species in the object as a result of comparing acquired signals to reference signals. The reference signals may be stored in a dictionary. Singular value decomposition may be applied to the dictionary and the acquired signals before comparing the acquired signals to the reference signals.

Claims30

Dependent claims

A method, comprising:

accessing a set of known signal evolutions, where the set of known signal evolutions have a first rank;
compressing members of the set of known signal evolutions into a set of compressed signal evolutions using singular value decomposition (SVD) basis compression, where members of the compressed signal evolutions have a lower rank than the first rank;
accessing an acquired nuclear magnetic resonance (NMR) signals, where the acquired NMR signals is acquired from a volume that contains one or more resonant species that simultaneously produced individual NMR signals in response to the application of magnetic resonance fingerprinting (MRF) radio frequency (RF) energy;
comparing the acquired NMR signals to members of the set of compressed signal evolutions to identify a matching compressed signal evolution, and
characterizing a resonant species in the volume as a function of the matching compressed signal evolution, where characterizing the resonant species comprises identifying one or more of, T1 relaxation associated with the resonant species, T2 relaxation associated with the resonant species, off-resonance relaxation associated with the resonant species, and diffusion weighted relaxation associated with the resonant species.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application: 14/257,348Filed 21 Apr 2014
Published: US 2015/0302579 A122 Oct 2015
Granted: 19 Feb 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification9 codes

G01R 33/5608
Image enhancement or correction, e.g. subtraction or averaging techniques , e.g. improvement of signal-to-noise ratio and resolution: data…
H04N 19/85
Methods or arrangements for coding, decoding, compressing or decompressing digital video signals: using pre-processing or post-processing…
G01R 33/448
Using nuclear magnetic resonance [NMR]: relaxometry, i.e. quantification of relaxation times or spin density
G06F 18/2134
Feature extraction, e.g. by transforming the feature space; Summarisation; Mappings, e.g. subspace methods: based on separation criteria, e.g.…