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AssigneeMeMed Diagnostics Ltd.
InventorsKfir Oved, Eran Eden, Ilan Ifergan
Estimating the term…
Antibiotics (Abx) are the worlds most misused drugs. Antibiotics misuse occurs when the drug is administered in case of a non-bacterial infection (such as a viral infection) for which it is ineffective. Overall, it is estimated that 40-70% of the worldwide Abx courses are mis-prescribed. The financial and health consequences of Abx over-prescription include the direct cost of the drugs, as well as the indirect costs of their side effects, which are estimated at >$15 billion annually. Furthermore, over-prescription directly causes the emergence of Abx-resistant strains of bacteria, which are recognized as one of the major threats to public health today. This generates an immediate need for reliable diagnostics to assist physicians in correct Abx prescription, especially at the point-of-care (POC) where most Abx are prescribed. Accordingly, some aspects of the present invention provide methods using biomarkers for rapidly detecting the source of infection and administrating the appropriate treatment.
A kit comprising a detection assay for distinguishing between bacterial and viral infections, the kit comprising monoclonal antibodies immobilized on a solid support, wherein said monoclonal antibodies comprise a first monoclonal antibody that specifically binds to TRAIL protein, a second monoclonal antibody that specifically binds to CRP protein and a third monoclonal antibody that specifically binds to IP10 protein when contacted to a whole blood sample or a fraction thereof from a subject, wherein the kit does not comprise more than two additional monoclonal antibodies which specifically bind to additional proteins which are differentially expressed in a statistically significant manner in subjects with a bacterial infection compared to subjects with a viral infection.
A kit comprising a detection assay for distinguishing between bacterial and viral infections, the kit comprising monoclonal antibodies immobilized on a solid support, wherein said monoclonal antibodies consist of a first monoclonal antibody that specifically binds to TRAIL protein, a second monoclonal antibody that specifically binds to CRP protein and a third monoclonal antibody that specifically binds to IP10 protein when contacted to a whole blood sample of a fraction thereof from a subject.
Dependencies are inferred from the claim text.