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US 10,209,255 B2Granted
Method for identifying a bacterial infection
AssigneeUniversity College Cardiff Consultants Limited
InventorsMatthias Eberl, Nicholas Topley, Chan-Yu Lin
Life of this patent
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Abstract
Method for identifying a bacterial infection The present application concerns a method for identifying the nature of a bacterial infection from a peritoneal sample, in particular, whether it is a Gram-negative or Gram-positive infection, based upon the determination of one or more cellular and/or humoral markers in a sample.
Claims6
A method for treating an individual suffering from a peritoneal Gram-negative bacterial infection, comprising:
- (a) obtaining a peritoneal sample from the individual;
- (b) examining said peritoneal sample in order to determine an amount of Vδ2+ T cells within the total T cell population of said sample and an amount of IL-10 in said sample;
- (c) where the amount of Vδ2+ T cells within the total T cell population is increased relative to an amount of Vδ2+ T cells within the total T cell population in a control sample from an individual not having a Gram-negative bacterial infection and the amount of IL-10 is increased relative to an amount of IL-10 in a control sample from an individual not having a Gram-negative bacterial infection, concluding that the individual from whom the peritoneal sample has been taken has a Gram-negative bacterial infection;
- and
- (d) administering to the individual a therapeutic for treating the peritoneal Gram-negative bacterial infection.
2 more elements
Dependencies are inferred from the claim text.