Cardiomyocyte containing device, manufacturing method and measuring method

A device for cardiac electrophysiology screening comprising:

• a substrate comprising a cavity, said substrate carrying a deformable layer configured for out-of-plane deformation extending over said cavity such that a central region of the deformable layer is not attached to the substrate, wherein a portion of said deformable layer covers said cavity, said portion having a surface comprising a pattern of grooves that are formed in the deformable layer and extend only partially through the deformable layer, said portion carrying an electrode structure and a fibronectin adhesive coating;
• a plurality of cardiomyocytes are configured to spontaneously assemble in an aligned and interconnected fashion into the pattern of grooves on the adhesive-coated surface portion of the deformable layer, such that meaningful readings from coordinated stretch/contraction cycles of the cardiomyocytes may be obtained;
• wherein the deformable layer is configured to trigger the assembling of the plurality of cardiomyocytes in the pattern of grooves,
• wherein the pattern of grooves have a dimension lower than 200 microns,
• wherein the electrode structure is formed in the pattern of grooves or on ridges.