High throughput sensitization detection devices and methods
AssigneeRutgers, The State University of New Jersey
InventorsTim Maguire, Martin L. Yarmush, Rene S. Schloss, Bhaskar Mitra, Rohit Jindal, Mehdi Ghodbane
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Abstract
This invention discloses devices and methods for high throughput skin sensitization detection. The devices comprise a microfabricated chamber comprising a region having one or more input channels and an outlet, and a face suitable for mounting a skin tissue and in fluidic communication with the region. The devices can be used in the methods for determining a prognosis of sensitization in an animal subject and identifying compounds that do not cause sensitization and thus are suitable for preparing cosmetic compositions.
Claims37
A device comprising a tubular wall defining a chamber, the chamber comprising:
- a region comprising (i) a solid substrate for attachment of cells, (ii) one or more input channels and (iii) an outlet, and
- a face that is suitable for mounting a skin tissue and is in fluid communication with the region,
- wherein the chamber and the region are capable of being filled with and holding a fluid, and the outlet comprises a plurality of weirs defining a plurality of channels that allow a flow of a liquid while blocking a cell.
Dependencies are inferred from the claim text.