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US 10,209,239 B1Granted
Method of making an aromagraph comprising ectopic olfactory receptors
AssigneeAromyx Corporation
InventorsChris Hanson, William Harries
Life of this patent
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Abstract
Biosensors are disclosed for detecting ligand binding at ectopic Olfactory Receptors. Methods of identifying novel ectopic Olfactory Receptors are also disclosed. Ligands for ectopic Olfactory Receptors are disclosed as well as methods for using these ligands to interact with ectopic Olfactory Receptors, including the use of such ligands in the treatment and/or mitigation of disease conditions.
Claims20
A method for making an Aromagraph, comprising the steps of:
- providing a plurality of biosensors wherein each biosensor comprises an ectopic Olfactory Receptor, a G protein subunit Gα, a G protein subunit Gβ, a G protein subunit Gγ, and a reporter, wherein binding of the ligand to the ectopic Olfactory Receptor sends a signal through the G protein subunits resulting in a signal from the reporter, wherein at least some of the biosensors have a different ectopic Olfactory Receptor, adding the ligand to the biosensors, detecting an increase for a reporter whereby binding of the ligand to the ectopic Olfactory Receptor is detected, and recording the reporter activity for the plurality of ectopic Olfactory Receptors.
Dependencies are inferred from the claim text.