Method of treatment for glioblastoma by administering a VEGF antagonist
AssigneeGenentech, Inc.
InventorsCarlos Bais, Richard Bourgon, Thomas Sandmann
Life of this patent
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Abstract
The invention provides methods and compositions to detect expression of one or more biomarkers for identifying and treating patients having glioblastomas who are likely to be responsive to VEGF antagonist therapy. The invention also provides kits and articles of manufacture for use in the methods.
Claims14
A method of treating a patient having a glioblastoma, the method comprising administering a VEGF antagonist to the patient, wherein the patient has a decrease in the expression level of at least one gene selected from the group consisting of AXL, BCL2L1, CD36, ETS1, ICAM2, IL17A, IRS2, PDGFRB, RPL13A, TGFB1, TNFRSF4, TNFSF4, and ZBTB16 relative to a reference expression level of the at least one gene, and wherein the reference level is the median level of expression of the at least one gene in a population of patients having a glioblastoma.
Dependencies are inferred from the claim text.