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US 10,208,354 B2Granted
NRG1 fusion genes in cancer
AssigneeUniversität zu Köln
InventorsLynnette Fernandez-Cuesta, Julie George, Dennis Plenker, Roman Thomas
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Abstract
The present invention relates to novel fusion genes comprising NRG1 and a further fusion partner, like CD74. The present invention provides for the use of these fusion genes in diagnosis as well as in medical intervention in cancer.
Claims14
A method for identifying a fusion gene in a sample comprising obtaining a sample from a human patient;
- and testing the sample by in vitro analysis to detect the presence of a fusion gene or of a gene product of a fusion gene in the sample, wherein
- a) said fusion gene or gene product is a CD74-NRG1 fusion gene, the gene comprising a sequence consisting of the sequence of SEQ ID NO:2, or the gene product of such a fusion gene, the gene product comprising a sequence consisting of the sequence of SEQ ID NO:1.
Dependencies are inferred from the claim text.