Providing cervical or oral mucosa canceration information from measurement of cells located toward the basal membrane side of epithelial tissue

A device for providing information pertaining to canceration of cells, the device comprising:

• a flow cell accommodating a flow of a measurement specimen including cells collected from cervical or oral mucosa epithelial tissue;
• an optical source configured to irradiate the measurement specimen flowing through the flow cell with light;
• a detector configured to detect a scattered light and a fluorescence from each of the cells and to output a scattered light signal and a fluorescence signal;
• and
• a processor programmed to:
• acquire, for each of the cells, a cell nucleus size from the fluorescence signal, a cell size from scattered light signal, and an amount of DNA from the fluorescence signal;
• calculate a ratio of the cell nucleus size and the cell size for each cell contained in the measurement specimen;
• extract measurement data of target cells comprising at least some of the cells located toward a basal membrane side of the cells existing in a surface layer in the epithelial tissue from the measurement data of the cells in the measurement specimen by comparing the calculated ratio with a first threshold value, so as to substantially exclude data of the surface layer cells existing in the surface layer and, the extracted measurement data including the cell nucleus size, the cell size and the amount of DNA for the target cells;
• count cells having an amount of DNA above a second threshold value based on the extracted measurement data;
• and
• output information pertaining to the canceration of cells based on a number of cells having an amount of DNA above the second threshold value, wherein the information indicates at least one of whether a reexamination is necessary, and whether a subject is positive for cancer of the cervix or oral mucosa.