US 10,208,332 B2Granted

Fluidic cartridge with valve mechanism

OwnerDavid Eberhart, William D. Nielsen +9inventors

InventorsDavid Eberhart, William D. Nielsen, Helen Franklin, Stevan B. Jovanovich, Dennis Lehto, Kaiwan Chear, James Klevenberg, Chungsoo Charles Park, Corey Smith, Philip Justus Wunderle, David King

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Abstract

Provided herein is a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to crush and close off a fluidic channel in the body. Also provided are a cartridge interface configured to engage the cartridge. Also provided is a system including a cartridge interface and methods of using the cartridge and system.

Claims29

Dependent claims

A cartridge comprising:

(a) a body comprising a malleable material;
and
(b) a layer comprising a deformable material bonded to a surface of the body and sealing a fluidic channel that communicates with one or more valve bodies formed in a surface of the body;
wherein:
(i) the one or more valve bodies comprise
a segment of the fluidic channel comprising a wall having a pair of ridges and a floor depressed into the surface,
and
(ii) the layer is bonded to the surface of the body and to the ridges such that the channel segment of the fluidic channel is sealed;
and
wherein a valve body sealed with the layer forms a valve configured to regulate fluid flow in the fluidic channel and closable by forcing the layer against the floor of the segment of the channel.

7 more elements

Dependencies are inferred from the claim text.

Facts

Application: 15/117,053Filed 30 Apr 2015 · us provisional application
Priority: 21 May 2014
Published: US 2017/0002399 A15 Jan 2017
Granted: 19 Feb 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification35 codes

C12Q 1/6806
Involving nucleic acids: preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
B01L 3/502707
By integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g.…
B01L 3/502715
By integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g.…
B01L 3/50273
By integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g.…

Family

Application62/001,533Us provisional application · filed 21 May 2014
Application62/067,404Us provisional application · filed 22 Oct 2014
Application62/067,120Us provisional application · filed 22 Oct 2014
Application62/067,429Us provisional application · filed 22 Oct 2014
Application62/069,473Us provisional application · filed 28 Oct 2014
Application62/069,752Us provisional application · filed 28 Oct 2014
US 2017/0002399 A1Pre-grant publication · published 5 Jan 2017
US 10,208,332 B2This patent

From the US filing history. Foreign family members aren’t listed.