Coryneform bacterium transformant and process for producing organic compound using the same
AssigneeResearch Institute of Innovative Technology for the Earth
InventorsMasayuki Inui, Masako Suda, Kazumi Hiraga, Takahisa Kogure
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Abstract
A coryneform bacterium transformant engineered by the following (A) to (D): (A) enhancement of 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase activity; (B) prevention, inhibition, or reduction of intracellular sugar uptake mediated by phosphotransferase system (PTS); (C) enhancement of intracellular sugar uptake activity mediated by a sugar transporter different from phosphotransferase system and enhancement of glucokinase activity; and (D) enhancement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity is capable of efficiently producing shikimic acid or the like from a sugar.
Claims21
A coryneform bacterium transformant engineered by the following (A) to (D):
- (A) enhancement of 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase activity by introducing a DNA that encodes the DHAP;
- (B) prevention, inhibition, or reduction of intracellular sugar uptake mediated by phosphoenolpyruvate:sugar phosphotransferase system (PTS);
- (C) enhancement of intracellular sugar uptake activity mediated by a sugar transporter different from phosphoenolpyruvate:sugar phosphotransferase system and enhancement of glucokinase activity by introducing a DNA that encodes the glucokinase;
- and
- (D) enhancement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity by introducing a DNA that encodes the GAPDH.
Corynebacterium glutamicum SKM7 (Accession Number:
- NITE BP-01903).
Dependencies are inferred from the claim text.