Compositions and methods to promote bone formation
AssigneeThe Research Foundation for The State University of New York
InventorsNikhil A. Thakur, Bryan S. Margulies
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Abstract
This disclosure relates to methods for promoting bone formation or reducing bone destruction. This disclosure also relates to methods for promoting the recruitment of mesenchymal stem cells (MSC) to a local site of injury or surgical intervention in bone to promote healing. In addition, this disclosure relates to methods for reducing or preventing mineral formation or bone growth, or reducing bone mass. The methods disclosed herein are useful for treating conditions such as osteoradionecrosis.
Claims14
A method for promoting bone formation in a subject in need thereof, comprising locally administering an OGFR antagonist selected from the group consisting of naloxone, naltrexone, and a salt thereof to a site of injury or site of surgical intervention in the subject in an amount effective to promote bone formation at the site of injury or the site of surgical intervention in the subject, wherein the amount effective to promote bone formation is a locally administered dose of the OGFR antagonist between 1 μM and 1 mM.
Dependencies are inferred from the claim text.