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US 10,208,296 B2Granted
Fusion proteins and methods thereof
AssigneeThe Trustees of Columbia University in the City of New York
InventorsAntonio Iavarone, Anna Lasorella, Raul Rabadan
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Abstract
The invention discloses oncogenic fusion proteins. The invention provides methods for treating gene-fusion based cancers.
Claims10
A cDNA encoding an EGFR-Septin-14 fusion protein comprising an EGFR portion fused to a Septin-14 portion, wherein the EGFR portion comprises amino acids:
- CTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKR
- TLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVY
- KGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRL
- LGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNY
- LEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVP
- IKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSIL
- EKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQR
- YLVIQ (amino acids 628-982 of SEQ ID NO:
- 5);
- and wherein the Septin-14 portion comprises amino acids:
- LQDKFEHLKMIQQEEIRKLEEEKKQLEGEIIDFYKMKAASEALQTQLSTD
- TKKDKHRKK (amino acids 983-1041 of SEQ ID NO:
- 5).
10 more elements
Dependencies are inferred from the claim text.