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US 10,208,294 B2Granted
Acyl-ACP reductase with improved properties
AssigneeReg Life Sciences, LLC
InventorsMathew Rude, Na Trinh, Andreas Schirmer, Jacob Gano
Life of this patent
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Abstract
The disclosure relates to acyl-ACP reductase (AAR) enzyme variants that result in improved fatty aldehyde and fatty alcohol production when expressed in recombinant host cells. The disclosure further relates to methods of making and using such AAR variants for the production of fatty alcohol compositions having particular characteristics.
Claims16
A variant acyl-ACP reductase (AAR) polypeptide comprising at least 90% sequence identity to the amino acid sequence of SEQ ID NO:
- 80, wherein said variant AAR polypeptide comprises a mutation at amino acid position 61, wherein the mutation is D61E, and wherein said AAR polypeptide catalyzes the conversion of an acyl-ACP to a fatty aldehyde.
Dependencies are inferred from the claim text.