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US 10,208,288 B2Granted
Differentiation of human embryonic stem cells into pancreatic endocrine cells
AssigneeJanssen Biotech, Inc.
InventorAlireza Rezania
Life of this patent
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Abstract
The present invention provides methods to promote differentiation of pancreatic endoderm cells to pancreatic endocrine rich clusters and to enhance insulin expression in hormone-expressing cells.
Claims14
A method of differentiating pancreatic endoderm cells into pancreatic hormone-expressing cells comprising culturing the pancreatic endoderm cells with an Ephrin ligand, wherein the method induces insulin expression.
A method of differentiating pancreatic endoderm cells into pancreatic endocrine cells comprising treating the pancreatic endoderm cells with an Ephrin ligand.
Dependencies are inferred from the claim text.