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US 10,208,225 B2Granted
Fluoro copolymers, immobilization of biomolecules, and microarrays
OwnerMarcella Chiariinventor
Life of this patent
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Abstract
Novel copolymers provide for improved microarray performance. The copolymers are based on acrylamide, acrylate, and/or methacrylate monomer repeat units and include specific, functional monomers including a fluorinated monomer to control surface hydrophilicity such as increase water contact angle and reduce spot size when the copolymer is used in thin film form on a microarray substrate. The copolymers are prepared by free-radical polymerization and are random in nature.
Claims17
A copolymer consisting of:
- a backbone consisting of N-substituted acrylamide, N-substituted methacrylamide, acrylate, or methacrylate repeat units,
- wherein the copolymer consists of at least four repeat units different from each other, wherein (A) at least one of the repeat units is a surface interacting monomer repeat unit, (B) at least one of the repeat units is adapted for covalently binding to a biological molecule, (C) at least one repeat units is a silane repeat unit, and (D) at least one repeat units is a fluorinated monomer repeat unit.
Dependencies are inferred from the claim text.