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US 10,208,121 B2Granted
Anti-Axl antagonistic antibodies
AssigneesBergen Teknologioverforing AS, Bergebio Asa
InventorsDavid Robert Micklem, Sergej Kiprijanov, James Bradley Lorens, Lavina Ahmed, Linn Hodneland Nilsson, Tone Sandal
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Abstract
Described are antibodies that specifically bind to the Axl protein and inhibit the interaction between Axl and the Axl-ligand, Gas6. Also disclosed are methods for the production and use of the anti-Axl antibodies.
Claims26
An antibody obtainable from either:
- A) the hybridoma UT-10C9-B9 (ECACC Accession No. 15121601);
- or
- B) the hybridoma WR-10G5-E5 (ECACC Accession No. 15121602).
An isolated antibody that binds Axl, wherein the antibody comprises:
- A) a heavy chain variable region (VH) that comprises a VH complementarity determining region (VH CDR) 1 with the amino acid sequence of SEQ ID NO:
- 5, a VH CDR2 with the amino acid sequence of SEQ ID NO:
- 6, and a VH CDR3 with the amino acid sequence of SEQ ID NO:
- 7, and a light chain variable region (VL) that comprises a VL complementarity determining region (VL CDR) 1 with the amino acid sequence of SEQ ID NO:
- 8, a VL CDR2 with the amino acid sequence of SEQ ID NO:
- 9, and a VL CDR3 with the amino acid sequence of SEQ ID NO:10;
- or
- B) a VH that comprises a VH CDR 1 with the amino acid sequence of SEQ ID NO:
- 23, a VH CDR2 with the amino acid sequence of SEQ ID NO:
- 24, and a VH CDR3 with the amino acid sequence of SEQ ID NO:
- 25, and a VL that comprises a VL CDR 1 with the amino acid sequence of SEQ ID NO:
- 26, a VL CDR2 with the amino acid sequence of SEQ ID NO:
- 27, and a VL CDR3 with the amino acid sequence of SEQ ID NO:
- 28.
11 more elements
Dependencies are inferred from the claim text.