Anti-PD-L1 antibodies and uses thereof
AssigneeI-Mab
InventorsLei Fang, Zhengyi Wang, Bingshi Guo, Jingwu Zang
Life of this patent
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Abstract
Provided are anti-PD-L1 antibodies or fragments thereof. The antibodies or fragments thereof specifically bind to the immunoglobulin C domain of the PD-L1 protein. In various example, the antibodies or fragments thereof include a VH CDR1 of SEQ ID NO: 1, a VH CDR2 of SEQ ID NO: 2, a VH CDR3 of SEQ ID NO: 3, a VL CDR1 of SEQ ID NO: 4, a VL CDR2 of SEQ ID NO: 5, and a VL CDR3 of SEQ ID NO: 6, or variants of each thereof. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and infectious diseases are also provided.
Claims18
An antibody or fragment thereof, wherein the antibody or fragment thereof has specificity to a human Programmed death-ligand 1 (PD-L1) protein and comprises a VH CDR1 comprising the amino acid sequence of SEQ ID NO:
- 1, a VH CDR2 comprising the amino acid sequence of SEQ ID NO:
- 2, a VH CDR3 comprising the amino acid sequence of SEQ ID NO:
- 3, a VL CDR1 comprising the amino acid sequence of SEQ ID NO:
- 4, a VL CDR2 comprising the amino acid sequence of SEQ ID NO:
- 5, and a VL CDR3 comprising the amino acid sequence of SEQ ID NO:
- 6.
An antibody or fragment thereof, wherein the antibody or fragment thereof has specificity to a human Programmed death-ligand 1 (PD-L1) protein and comprises a heavy chain variable region comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 7-26 and a light chain variable region comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 27-33.
An isolated antibody or fragment thereof, wherein the antibody or fragment thereof has specificity to a human PD-L1 protein and comprises:
- (a) a VH CDR1 of SEQ ID NO:
- 1, or a variant of SEQ ID NO:
- 1 having a single substitution, deletion or insertion at location 1, 2 or 5 of SEQ ID NO:
- 1;
- (b) a VH CDR2 of SEQ ID NO:
- 2, or a variant of SEQ ID NO:
- 2 having a single substitution, deletion or insertion at location 7, 8, 14 or 15 of SEQ ID NO:
- 2;
- (c) a VH CDR3 of SEQ ID NO:
- 3, or a variant of SEQ ID NO:
- 3 having a single substitution, deletion or insertion at location 1, 2, 3, 4, 5 or 6 of SEQ ID NO:
- 3;
- (d) a VL CDR1 of SEQ ID NO:
- 4, or a variant of SEQ ID NO:
- 4 having a single substitution, deletion or insertion at location 3 of SEQ ID NO:
- 4;
- (e) a VL CDR2 of SEQ ID NO:
- 5, or a variant of SEQ ID NO:
- 5 having a single substitution, deletion or insertion at location 1, 2, 3, 4, 5 or 6 of SEQ ID NO:
- 5 and
- (f) a VL CDR3 of SEQ ID NO:
- 6, or a variant of SEQ ID NO:
- 6 having a single substitution, deletion or insertion at location 11 or 2 of SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.