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AssigneeAlderbio Holdings LLC
InventorsBrian Robert Kovacevich, Leon F. Garcia-Martinez, Katie Olson Anderson, Benjamin H. Dutzar, Jens J. Billgren, John A. Latham, Danielle M. Mitchell, Patricia Dianne McNeill, Nicole M. Janson, Maria-Cristina Loomis
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The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-CGRP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-CGRP antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-CGRP antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with CGRP.
An isolated polynucleotide or polynucleotides which encode an anti-human calcitonin gene related peptide (CGRP) antibody or antibody fragment, wherein said antibody or antibody fragment comprises (i) a variable light (VL) chain polypeptide that comprises the VL complementarity determining region (CDR) polypeptides CDR1, CDR2, and CDR3, respectively, of SEQ ID NO:
Dependencies are inferred from the claim text.