Fast and efficient conjugation method based on thiourea-catechol coupling
AssigneeThe Chinese University of Hong Kong
InventorsLiming Bian, Yang Xu, Kongchang Wei, Pengchao Zhao
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Abstract
The present invention provides novel methods and compositions useful for a fast and efficient chemical conjugation method of making hetero-arm polymers based on thiourea-catechol coupling. This novel conjugation method are useful in a wide variety of applications relating to the modification, ligation, and conjugation of large or small molecules to each other as well as to solid surface, including the making of adhesive materials such as hydrogels.
Claims12
A method of preparing a multi-compound chemical structure using a catechol-functionalized compound and a thiourea-functionalized di-compound polymer, comprising the steps of:
- (a) oxidizing the catechol-functionalized compound in the presence of an oxidizing agent to form the corresponding oxidized catechol-functionalized compound;
- and
- (b) conjugating the oxidized catechol-functionalized compound with the thiourea-functionalized di-compound polymer to form a catechol-conjugated tri-compound polymer.
Dependencies are inferred from the claim text.