Albumin variants and uses thereof
AssigneeUniversity of Oslo
InventorsJan Terje Andersen, Inger Sandlie, Malin Bern
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Abstract
The present invention relates to albumin variants with an improved affinity for the neonatal Fc receptor (FcRn) and uses thereof, and in particular to the use of such albumin variants as carriers for immunogens. In some embodiments, the present invention relates to vaccines (e.g., vaccines for mucosal delivery) comprising albumin/immunogen fusion proteins.
Claims12
A variant human serum albumin (HSA) polypeptide that binds to FcRn with increased affinity relative to wild type HSA, wherein said polypeptide comprises substituted amino acids, wherein said substitutions are selected from the group consisting of K573Y/I523G, K573Y/I523G/T527M, K573Y/E505Q/T527M, K573Y/T527M, K573P/I523G, K573P/I523G/T527M, K573P/E505Q/T527M, V547A/K573P, V547A/E505Q/K573P/T527M.
Dependencies are inferred from the claim text.