Back to results
US 10,208,092 B2Granted
Modified kappa light chain-binding polypeptides
AssigneeGE Healthcare Bio-Process R&D AB
InventorsGustav Rodrigo, Mats Ander, Tomas Bjorkman
Life of this patent
Estimating the term…
Abstract
The invention discloses kappa light chain-binding polypeptide comprising a mutated binding domain of Peptostreptococcus protein L, wherein at least one asparagine residue of a parental domain defined by, or having at least 95% or 98% sequence homology with, SEQ ID NO: 2-6 or 2 has been mutated to another amino acid residue which is not asparagine, proline or cysteine.
Claims17
A kappa light chain-binding polypeptide comprising at least one mutated binding domain of Peptostreptococcus Protein L, in which the domain has been mutated at positions:
- N45A and comprising the amino acid sequence defined by SEQ ID NO:
- 7;
- N10Q,N45A and comprising the amino acid sequence defined by SEQ ID NO:
- 8;
- N45A,N60Q and comprising the amino acid sequence defined by SEQ ID NO:
- 9;
- or
- N10Q,N45A,N60Q and comprising the amino acid sequence defined by SEQ ID NO:
- 11.
6 more elements
Dependencies are inferred from the claim text.