Modulation of complement activity

A polypeptide of the formula R1-Xaa0-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Xaa13-Xaa14-Xaa15-Xaa16-R2, wherein:

• R1 is selected from the group consisting of an acetyl group, H, an acyl group, a heptanoyl group, an amide, a carbamate, urea, polyethylene glycol (PEG), hydroxyalkyl starch and chloroacetic acid, or is absent;
• Xaa0 is absent or Met;
• Xaa1 is selected from the group consisting of Cys, Lys, (S)-2-amino-5-azidopentanoic acid, and 3-thiopropionic acid, or is absent;
• Xaa2 is selected from the group consisting of Val, Ala, and D-Ala, or is absent;
• Xaa3 is selected from the group consisting of Glu, norvaline, and Ala, or is absent;
• Xaa4 is selected from the group consisting of Arg, Cys, Ala, Ser, and norvaline, or is absent;
• Xaa5 is selected from the group consisting of Phe, Tyr, N-methyl-tyrosine, and Ala, or is absent;
• Xaa6 is selected from the group consisting of Cys, Glu, N-methyl-glutamic acid, Asp, (S)-2-aminopent-4-ynoic acid, and Ala;
• Xaa7 is selected from the group consisting of Asp, Asn, N-methyl-asparagine, alpha-methyl L-aspartic acid, (S)-2-amino-3-(1H-tetrazol-5-yl)propanoic acid, N-methyl-aspartic acid, cycloleucine, 4-amino-tetrahydro-pyran-4-carboxylic acid, and Ala;
• Xaa8 is selected from the group consisting of tert-butylglycine, Val and Ala;
• Xaa9 is Tyr;
• Xaa10 is selected from the group consisting of 7-azatryptophan, Trp, 3-aminomethyl-L-phenyalanine, N-methyl-tryptophan, and 1-methyl-tryptophan;
• Xaa11 is Glu;
• Xaa12 is Tyr;
• Xaa13 is Pro;
• Xaa14 is selected from the group consisting of cyclohexylglycine, phenylglycine, D-phenylglycine, N-methyl-phenylglycine, amino isobutyric acid, and Ala, or is absent;
• Xaa15 is selected from the group consisting of norvaline, Lys, and Pro, or is absent;
• Xaa16 is absent or selected from the group consisting of N-ε-palmitoyl lysine, N-ε-lauryl lysine, N-ε-capryl lysine, N-ε-caprylic lysine, B20, B28, K14, Cys, and Lys;
• and
• R2 is —NH2 or is absent.