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US 10,208,083 B2Granted
Esters of steroidal lactam and bis(2-chloroethyl) aminophenoxy propanoic acid derivatives
AssigneesGalenica AB, Energonbio Technologies S.A.
InventorDimitrios Trafalis
Life of this patent
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Abstract
Novel homo-aza-steroidal esters with alkylating bis(2-chloroethyl)aminophenoxy propanoic acid and substituted derivatives, processes for their preparation, pharmaceutical compositions containing them and use thereof in the treatment of cancer.
Claims10
A compound of formula (I) or a pharmaceutically acceptable salt thereof
- wherein
- R1 is selected from the group consisting of
- R2 is selected from the group consisting of H, —CH3, —CH═CH2, —CH2—CH3, —CH2CH2CH3,
- and, R3 is selected from the group consisting of H, —OH, —NH2.
1 more element
A method of treating one of ovarian cancer, breast cancer, prostate cancer or leukemia, the method comprising:
- administering to a patient a compound of formula (I), or a pharmaceutically acceptable salt thereof,
- wherein
- R1 is selected from the group consisting of
- R2 is selected from the group consisting of H, —CH3, —CH═CH2, —CH2—CH2, —CH2CH2CH3,
- and,
- R3 is selected from the group consisting of H, —OH, —NH2.
3 more elements
Dependencies are inferred from the claim text.