Methods of treating and/or preventing affective disorders of the nervous system (depression) using aminosterols
AssigneeEnterin Laboratories, Inc.
InventorMichael Zasloff
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Abstract
This invention relates to methods of stimulating the activity of the human and animal enteric nervous system. The method comprises orally administering an aminoserol, such as squalamine, a naturally occurring aminosterol isolated from Squalus acanthias, or derivatives thereof, to a subject in need.
Claims23
A method of treating depression in a subject, comprising orally administering to the subject a composition comprising a pharmaceutically acceptable grade of at least one aminosterol, or a pharmaceutically acceptable salt or derivative thereof, in an amount sufficient to produce a beneficial effect.
A method of treating or preventing depression in a subject, comprising orally administering to the subject a composition comprising a pharmaceutically acceptable grade of at least one aminosterol, or a pharmaceutically acceptable salt or derivative thereof, in an amount sufficient to produce a beneficial effect, wherein the aminosterol is administered in combination with at least one additional active agent to achieve either an additive or synergistic effect, and wherein the additional active agent is selected from tricyclic antidepressants, monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, and serotonin and norepinephrine reuptake inhibitors.
Dependencies are inferred from the claim text.