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US 10,208,075 B2Granted
Pyrazole compounds and method for making and using the compounds
AssigneeRigel Pharmaceuticals, Inc.
InventorsRyan Kelley, Hui Li, Thilo Heckrodt, Yan Chen, Darren McMurtrie, Kin Tso, Vanessa Taylor, Rajinder Singh, Rose Yen, Jack Maung
Life of this patent
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Abstract
Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.
Claims17
A compound having a formula
- or a pharmaceutically acceptable salt thereof, wherein:
- R2 is aliphatic, cycloaliphatic, heteroaliphatic, or heterocycloaliphatic;
- each of R4, R5, R6, and R7 independently is H, aliphatic, alkoxy, halogen, —O-heterocyclyl or heterocyclic;
- R8 and R9 are each independently H or aliphatic;
- R10 is H, aliphatic, carboxyl ester, acyl, alkyl phosphate, alkyl phosphonate or aralkyl;
- and
- R11 and R12 are each independently H or aliphatic.
4 more elements
Dependencies are inferred from the claim text.