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US 10,208,067 B2Granted
Compounds for treating spinal muscular atrophy
AssigneeHoffmann-La Roche Inc.
InventorsRobert Jack Gillespie, Hasane Ratni, Jerome Charles Sarie
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Abstract
The present invention provides compounds of formula (I) wherein A, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
Claims33
A compound of formula (I):
- wherein
- X is N and Y is CR3 or X is CR4 and Y is N;
- R1 is selected from hydrogen, cyano, halo, C1-7-alkyl, C1-7-haloalkyl, C1-7-alkoxy or C3-8-cycloalkyl;
- R2 is selected from hydrogen, cyano, halo, C1-7-alkyl, C1-7-haloalkyl, C1-7-alkoxy or C3-8-cycloalkyl;
- R3 is selected from hydrogen, cyano, halo, C1-7-alkyl, C1-7-haloalkyl, C1-7-alkoxy or C3-8-cycloalkyl;
- R4 is selected from hydrogen, cyano, halo, C1-7-alkyl, C1-7-haloalkyl, C1-7-alkoxy or C3-8-cycloalkyl;
- A is N-heterocycloalkyl or NR5R6, wherein N-heterocycloalkyl comprises 1 or 2 nitrogen ring atoms and is optionally substituted with 1, 2, 3 or 4 substituents selected from R7;
- R5 is heterocycloalkyl comprising 1 nitrogen ring atom, wherein heterocycloalkyl is optionally substituted with 1, 2, 3 or 4 substituents selected from R7;
- R6 is hydrogen, C1-7-alkyl or C3-8-cycloalkyl;
- R7 is independently selected from C1-7-alkyl, amino, amino-C1-7-alkyl, C3-8-cycloalkyl, heterocycloalkyl, and heterocycloalkyl-C1-7-alkyl or two R7 together form C1-7-alkylene;
- with the proviso that if A is N-heterocycloalkyl comprising only 1 nitrogen ring atom, then at least one R7 substituent comprises a basic nitrogen;
- or a pharmaceutically acceptable salt thereof.
9 more elements
Dependencies are inferred from the claim text.