Back to results
US 10,208,066 B2Granted
Imidazopyridazine compounds and their use
AssigneeHutchison Medipharma Limited
InventorsWei-Guo Su, Guangxiu Dai, Welhan Zhang, Wei Deng
Life of this patent
Estimating the term…
Abstract
This disclosure provides novel imidazopyridazine compounds of formula (I) and pharmaceutical acceptable salt thereof, pharmaceutical compositions containing them, a process for preparing them, and their practical effect in inhibiting PI3K and potential use in treating a disease responsive to inhibition of PI3K, for example, an inflammatory disease, autoimmune disease or cancer.
Claims16
A compound of formula (I):
- and/or a pharmaceutically acceptable salt thereof, and/or solvates, racemic mixture, enantiomers, diasteromers, and tautomers thereof, wherein
- Ar is aryl or heteroaryl, each of which is optionally substituted with one or more groups chosen from deuterium, halo, —CN, —OH, —SH, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, —O(C1-6 alkyl), —(C1-6 alkyl)OH, —NH2, —NH(C1-6 alkyl), —N(C1-6 alkyl)(C1-6 alkyl), and —S(O)2(C1-6 alkyl);
- W is chosen from heteroaryl and N(R3)heteroaryl, wherein said heteroaryl is optionally substituted with one or more groups chosen from halo, —CN, —OH, —SH, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, —O(C1-6 alkyl), —(C1-6 alkyl)OH, —NH2, —NH(C1-6 alkyl), —N(C1-6 alkyl)(C1-6 alkyl), —COOH, —C(O)NH2, —C(O)NH(C1-6 alkyl), —C(O)N(C1-6 alkyl)(C1-6 alkyl), —SO2(C1-6 alkyl), phenyl, and 5- or 6-membered heteroaryl;
- in which each of said phenyl or 5- or 6-membered heteroaryl as the substituent of W is optionally substituted with one or more groups chosen from halo, —CN, —OH, —SH, C1-6 alkyl, C1-6 haloalkyl, —O(C1-6 alkyl), —(C1-6 alkyl)OH, —NH2, —NH(C1-6 alkyl), and —N(C1-6 alkyl)(C1-6 alkyl);
- R1 is independently chosen from H, halo, —CN, C1-6 alkyl, C1-6 haloalkyl, —(C1-6 alkyl)OH, —(C1-6 alkyl)O(C1-6 alkyl), and C2-6 alkynyl;
- R2 is chosen from H, C1-6 alkyl, and C3-8 cycloalkyl, each of which except for H, is optionally substituted with one or more groups chosen from halo, —CN, C1-6 alkyl, C1-6 haloalkyl, and —OH;
- R3 is H or C1-6 alkyl;
- m is 1 or 2.
5 more elements
A compound of formula (II)
- and/or a salt thereof;
- and/or a racemic mixture or enantiomer thereof;
- wherein
- Ar is aryl or heteroaryl, each of which is optionally substituted with one or more groups chosen from deuterium, halo, —CN, —OH, —SH, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, —O(C1-6 alkyl), —(C1-6 alkyl)OH, —NH2, —NH(C1-6 alkyl), —N(C1-6 alkyl)(C1-6 alkyl), and —S(O)2(C1-6 alkyl);
- and
- R2 is chosen from H, C1-6 alkyl, and C3-8 cycloalkyl, each of which except for H, is optionally substituted with one or more groups chosen from halo, —CN, C1-6 alkyl, C1-6 haloalkyl, and —OH.
3 more elements
Dependencies are inferred from the claim text.