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US 10,208,060 B2Granted
Inhibitors of HIF prolyl hydroxylase
AssigneeMerck Sharp & Dohme Corp.
InventorsJiaqiang Cai, Alejandro Crespo, John Debenham, Xiaoxing Du, Ping Liu, Rongqiang Liu, Christina B. Madsen-Duggan, Weiguo Quan, Christopher Sinz, Liping Wang
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Abstract
The present invention concerns compounds of formula I or a pharmaceutically acceptable salt thereof which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
Claims3
A compound which is:
- 2-(4-Hydroxy-2-oxo-1-(4-(trifluoromethyl)phenyl)-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetic acid;
- 2-(1-(4-chlorophenyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetic acid;
- 2-(1-(4-fluorophenyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetic acid;
- 2-(4-hydroxy-2-oxo-1-phenyl-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetic acid;
- 2-(4-hydroxy-1-(4-methoxyphenyl)-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetic acid;
- 2-(4-hydroxy-2-oxo-1-(4-(trifluoromethoxy)phenyl)-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetic acid;
- 2-(4-hydroxy-2-oxo-1-(m-tolyl)-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetic acid;
- 2-(4-hydroxy-2-oxo-1-(p-tolyl)-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetic acid;
- 2-(1-(4-cyanophenyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetic acid;
- and
- 2-(4-hydroxy-1-(5-methoxypyridin-2-yl)-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetic acid;
- or a pharmaceutically acceptable salt thereof.
9 more elements
Dependencies are inferred from the claim text.