Compounds and methods of treating ocular disorders
AssigneeCase Western Reserve University
InventorsKrzysztof Palczewski, Akiko Maeda, Marcin Golczak
Life of this patent
Estimating the term…
Abstract
A method of treating an ocular disorder in a subject associated with aberrant all-trans-retinal clearance in the retina, the method comprising administering to the subject a therapeutically effective amount of a primary amine compound of formula: wherein R1 is an aliphatic and/or aromatic compound.
Claims20
A method of treating a retinal pathology associated with aberrant all-trans-retinal clearance in the retina outer segment of a subject in need thereof, comprising administering to a subject in need thereof a therapeutically effective amount of a primary amine compound of formula:
- or a pharmaceutically acceptable salt thereof, wherein:
- R2 is hydrogen or (C1-C6) straight or branched unsubstituted or substituted alkyl;
- R3 is (C1-C8) straight or branched unsubstituted or substituted alkyl, (C2-C8) straight or branched alkenyl, (C3-C7) cycloalkyl, (C1-C6) alkoxy, alkylcycloalkyl, alkylalkoxy, alkyl OH, alkylphenyl, alkylphenoxy, phenyl, or substituted phenyl;
- and
- R4 is hydrogen or (C1-C6) straight or branched unsubstituted or substituted alkyl or carboxyl, wherein the retinal pathology is macular degeneration, Stargardt's disease, geographic atrophy, Leber's congenital amaurosis, or retinitis pigmentosa.
A method of treating a retinal pathology associated with aberrant all-trans-retinal clearance in the retina outer segment of a subject in need thereof, comprising administering to a subject in need thereof a therapeutically effective amount of a primary amine compound of formula:
- or a pharmaceutically acceptable salt thereof, wherein:
- R2 is hydrogen, (C1-C6) straight or branched alkyl, or phenyl;
- R3 is (C1-C8) straight or branched alkyl, (C2-C8) straight or branched alkenyl, (C3-C7) cycloalkyl, (C1-C6) alkoxy, alkylcycloalkyl, alkylalkoxy, alkyl OH, alkylphenyl, alkylphenoxy, phenyl, or substituted phenyl;
- R4 is hydrogen;
- and
- R2 is straight or branched (C1-C6) alkyl, or phenyl when R3 is methyl, wherein the retinal pathology is macular degeneration, Stargardt's disease, geographic atrophy, Leber's congenital amaurosis, or retinitis pigmentosa.
A method of treating Stargardt's disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a primary amine compound selected from (S)-3-(Aminomethyl)-5-methylhexanoic acid, (R)-3-(Aminomethyl)-5-methylhexanoic acid, and racemic mixtures thereof.
Dependencies are inferred from the claim text.