Aza-pyridone compounds and uses thereof

A compound of Formula (I), or a pharmaceutically acceptable salt thereof, wherein the compound of Formula (I) has the structure:

• wherein:
• R1 is selected from the group consisting of hydrogen, an unsubstituted C1-4 alkyl, an optionally substituted heterocyclyl, —C(═O)Y1, —C(═O)—O—Y1, —(CH2)—O—C(═O)—Y1, —(CH2)—O—C(═O)—O—Y1, —(CHCH3)—O—C(═O)—Y1 and —(CHCH3)—O—C(═O)—O—Y1;
• R2 is selected from the group consisting of hydrogen, an optionally substituted C1-6 alkyl, an optionally substituted C2-6 alkenyl, an optionally substituted heterocyclyl, an optionally substituted cycloalkyl(C1-6 alkyl), an optionally substituted aryl(C1-6 alkyl), an optionally substituted heteroaryl(C 1-6 alkyl) and an optionally substituted heterocyclyl(C1-6 alkyl);
• R3a and R3b are independently hydrogen or an optionally substituted C1-4 alkyl;
• R4 is selected from the group consisting of:
• R6A and R6B are each hydrogen, each fluoro or each chloro;
• or
• R6A and R6B are independently hydrogen, an unsubstituted C1-4 alkyl or an unsubstituted C2-4 alkynyl, provided that at least one of R6A and R6B is an unsubstituted C1-4 alkyl or an unsubstituted C2-4 alkynyl;
• R6C is an optionally substituted aryl or an optionally substituted heteroaryl;
• R6D is an optionally substituted heteroaryl;
• R6E and R6F are each hydrogen or each fluoro;
• R6G and R6H are each fluoro or each chloro;
• R5 is selected from the group consisting of hydrogen, halogen, —CN, an optionally substituted C1-6 alkyl, an optionally substituted aryl, an optionally substituted heteroaryl, —CH2OH, —CH(Y2)(OH) and —C(O)Y2;
• Y1 and Y2 are independently selected from the group consisting of an optionally substituted C1-6 alkyl, an optionally substituted C3-6 cycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocyclyl, a mono-substituted amino group, a di-substituted amino and —C(R7)2NHR8;
• and
• each R7 and R8 are independently hydrogen or an optionally substituted C1-4 alkyl;
• and
• provided that:
• when R4 is
• wherein R6A and R6B are each hydrogen, and R2 is hydrogen, CH3, —CH2CH3, —CH2CH2CH3, —CH2CH2CH2CH3, —CH(CH3)2, —CH(CH2CH3)2, —CH2CH(CH3)2, —CH(CH3)CF3, —CH2—(C3-cyclopropyl), tetrahydro-2H-pyran, —CH2CH2OH, —CH2CH2OCH3 or —C(CH3)2CH2OCH3;
• then R1 is not hydrogen, —C(═O)CH3, —C(═O)CH(CH3)2, —C(═O)CH2CH(CH3)2, —C(═O)—(C5-6-cycloalkyl), —C(═O)-(tetrahydro-2H-pyran), —C(═O)—O—CH(CH3)2, —C(═O)—O—CH2CH(CH3)2, —CH2—O—C(═O)CH(CH3)(NH2), —CH2—O—C(═O)CH(CH(CH3)2)(NH2) or —CH2—O—C(═O)C((CH3)2)(NH2);
• when R4 is
• wherein R6A and R6B are each fluoro, and R2 is —CH3, —CH2CH3, —CH2CH2CH3, —CH2CH2CH2CH3, —CH(CH3)2, —CH2CH(CH3)2, —CH2—(C3-cyclopropyl), -unsubstituted benzyl, —CH2CH2OH or —CH2CH2OCH3;
• then R1 is not hydrogen, —CH2CH3, —C(═O)CH3, —C(═O)CH(CH3)2, —CH2—O—C(═O)—O-(phenyl substituted with methyl and nitro), —CH2—O—C(═O)—NH—CH2CH2-(morpholine), —CH2—O—C(═O)CH(CH(CH3)2)(NH2) or —CH2—O—C(═O)NH(CH3);
• when R4 is
• wherein R6A and R6B are each chloro, and R2 is —CH3, —CH2CH3, —CH2CH2CH3, —CH2CH2CH2CH3, —CH(CH3)2, —CH2CH(CH3)2, —CH2—(C3-cyclopropyl), —CH2CH2OH or —CH2CH2OCH3;
• then R1 is not hydrogen or —C(═O)CH(CH3)2;
• when R4 is
• wherein one of R6A and R6B is an unsubstituted C1-4 alkyl;
• then R1 is not hydrogen;
• when R4 is
• wherein R6E and R6F are each hydrogen, and R2 is —CH3, —CH2CH3, —CH2CH2CH3, —CH2CH2CH2CH3, —CH(CH3)2, —CH2CH(CH3)2, —CH2—(C3-cyclopropyl), an unsubstituted benzyl, —CH(CH3)CF3, —CH2CH2OH or —CH2CH2OCH3;
• then R1 is not hydrogen or —C(═O)CH(CH3)2;
• when R4 is
• wherein R6E and R6F are each fluoro, and R2 is —CH3, —CH2CH3, —CH2CH2CH3, —CH2CH2CH2CH3, —CH(CH3)2, —CH2CH(CH3)2, —CH2—(C3-cyclopropyl), —CH2CH2OH or —CH2CH2OCH3;
• then R1 is not hydrogen or —C(═O)CH(CH3)2;
• when R4 is
• wherein R6C is pyrazolyl and R6D is unsubstituted phenyl;
• then R6C is a di-substituted pyrazolyl;
• wherein when R4 is
• wherein R6C is an optionally substituted imidazolyl or an optionally substituted pyridinyl;
• then R6D is not an optionally substituted phenyl;
• and
• when R4 is
• wherein R6G and R6H are each fluoro or each chloro, and R2 is —CH3;
• then R1 is not hydrogen.