Methods for inhibiting fascin

A method of inhibiting fascin expression or fascin activity, comprising administering an effective amount of a fascin inhibitor to a cell with fascin expression to thereby inhibit fascin expression or fascin activity in the cell, wherein the fascin inhibitor is a compound having the following structure:

• or a tautomer thereof, and/or a pharmaceutically acceptable salt thereof,
• wherein
• L1 is selected from the group consisting —(C(R8)2)j—, —(C(R8)2)q—C(O)—(C(R8)2)r—, —(C(R8)2)q—C(O)N(R8)—(C(R8)2)r—, —(C(R8)2)q—N(R8)C(O)—(C(R8)2)r—, —(C(R8)2)q—N(R8)S(O)2—(C(R8)2)r—, —(CH2)q—S(O)2N(R8)—(CH2)r—, —S—, —O— and —NR8—;
• each R6 is independently selected from the group consisting of halo and lower alkyl optionally substituted with 1-3 halo;
• or two adjacent R6 on a phenyl ring form a 5- or 6-membered cycloalkyl or heterocycloalkyl fused with the phenyl ring;
• R8 is hydrogen or lower alkyl;
• j is 1, 2 or 3;
• q is 0 or 1;
• r is 0 or 1;
• and
• u is 1, 2 or 3.