Diazabicyclooctane compounds

A compound of Formula (II)

• wherein
• R1 is benzyl, H or SO3M;
• M is H, or an inorganic or organic cation;
• R2 is H, (C1-C8)alkyl, —NHC(O)CH2-aryl, —NHC(O)CH2-heteroaryl, —NHC(O)CH(NH2)-aryl or —NHC(O)(CH2)3CH(NH2)—CO2R3;
• A is a 5- to 6-membered heterocyclic ring containing at least one nitrogen atom and substituted with one or more groups selected from halogen, CN, (C1C8)alkyl, (C1-C8)haloalkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, OR3, NR3R3, C(O)R3, [(C1-C8)alkylene]OR3, [(C1-C8)alkylene]OC(O)R3, [(C1-C8)alkylene]OC(O)NR3R3, [(C1-C8)alkylene]NR3R3, C(O)NR3R3, C(O)[(C1-C8)alkylene]NR3R3, CO2R3, C(S)NR3R3, SR3, S(O)R3, SO2R3 and SO2NR3R3;
• R3 is independently H, (C1-C8)alkyl, (C1-C8)haloalkyl, cycloalkyl, heterocyclyl, [(C1-C8)alkylene] heterocyclyl, aryl, [(C1-C8)alkylene] aryl or heteroaryl;
• and
• wherein any alkyl, cycloalkyl, heterocyclyl, heteroaryl or aryl is optionally substituted with 1, 2, or 3 groups selected from OH, CN, SH, SO2NH2, halogen, NH2, NHCNH, C(O)NH2, C(O)N(CH3)2, C(O)NH(aryl-COOH), C(NH)CH3, CH2(NH)SO2NH2, COOH, COOCH3, acetyl, (C1-C8)alkyl, S(C1-C8)alkyl, S(C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C1-C8)haloalkyl, (C1-C8)thioalkyl and heterocyclyl,
• or a pharmaceutically acceptable salt or ester thereof.