Histone demethylase inhibitors
AssigneeCelgene Quanticel Research, Inc.
InventorsAmogh Boloor, Toufike Kanouni, Jeffrey Alan Stafford, James Marvin Veal, Michael Brennan Wallace
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Abstract
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrido[3,4-d]pyrimidin-4-one derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer, melanoma, and the like.
Claims8
A substituted pyrido[3,4-d]pyrimidin-4-one derivative compound having the structure of Formula (VIa),
- or pharmaceutically acceptable salt thereof, wherein,
- X is halogen and n is 0 or 1;
- Z is N or C—H;
- R is alkyl, aryl, aralkyl, carbocyclylalkyl, or heterocarbocyclyl;
- wherein an effective amount of said substituted pyrido[3,4-d]pyrimidin-4-one derivative compound inhibits histone demethylase activity.
Dependencies are inferred from the claim text.