Quinoline derivative

A compound represented by general formula (I)

• wherein
• R1 represents (1) a C1-8 alkyl group optionally substituted with one to five R11, (2) a C3-7 carbon ring optionally substituted with one to five R12, or (3) a 4- to 7-membered heterocycle optionally substituted with one to five R13, where when the C1-8 alkyl group represented by R1 is a branched alkyl group, C1-3 alkyl groups branched from the same carbon atom may together form a saturated C3-7 carbon ring;
• R2 represents (1) a C1-8 alkyl group optionally substituted with one to five R21, (2) a C2-8 alkenyl group optionally substituted with one to five R22, (3) a C2-8 alkynyl group optionally substituted with one to five R23, (4) a —OR24 group, (5) a C3-7 carbon ring optionally substituted with one to five R25, (6) a 4- to 7-membered heterocycle optionally substituted with one to five R26, (7) a halogen atom, (8) a C(O)R27 group, or (9) a C(O)NR28R29 group, where when m is two or more and R2 is on adjacent carbon atoms and when R2 represents a C1-3 alkyl group optionally substituted with an amino group, or a C2-3 alkenyl group optionally substituted with an amino group, R2 bonded to the adjacent carbon atoms, together with the carbon atoms, may form a 5- to 7-membered cyclic group optionally substituted with one to three R20, and when R1 represents a C1-3 alkyl group, together with the atom on the 5- to 7-membered cyclic group formed by the plurality of R2, may further form a 5- to 7-membered cyclic group;
• wherein the ring moiety of the follow in structure of the general formula (I):
• is a ring selected from the group consisting of:
• wherein p represents an integer of 0 to 3, in which when p is 2 or 3, a plurality of R20 may be the same as or different from each other, and each occurrence of —N— appearing in the foregoing rings independently represents —NH— when it is not substituted by R20;
• R3 represents (1) a C1-4 alkyl group, (2) a halogen atom, (3) a C1-4 haloalkyl group, or (4) —OR31 group;
• R4 represents (1) a C1-4 alkoxy group, (2) a C1-4 haloalkyl group, (3) an —OR41 group, (4) a C1-4 alkyl group, (5) a C2-4 alkenyloxy group, or (6) a C2-4 alkynyloxy group;
• R11 represents (1) —OR101 group, (2) an SO2R102 group, (3) an NR103R104 group, or (4) a C3-7 carbon ring optionally substituted with one to three halogen atoms;
• R12 represents (1) a C1-4 alkyl group optionally substituted with an amino group, (2) a C1-4 haloalkyl group, or (3) a halogen atom;
• R13 represents (1) a C1-4 alkyl group optionally substituted with an amino group, (2) a C1-4 haloalkyl group, or (3) a halogen atom;
• R101 represents (1) a hydrogen atom, or (2) a C1-4 alkyl group;
• R102 represents (1) a hydrogen atom, or (2) a C1-4 alkyl group;
• R103 and R104 each independently represent (1) a hydrogen atom, or (2) a C1-4 alkyl group;
• R20 represents (1) a C1-4 alkyl group, (2) a halogen atom, (3) a C1-4 haloalkyl group, (4) an oxo group, (5) an —OR201 group, (6) a COOR205 group, (7) an NR206R207 group, or (8) a COR208 group, where when two R20 represent a C1-3 alkyl group and are on the same carbon atom, the R20 together may form a C3-7 saturated carbon ring;
• R21, R22, and R23 each independently represents (1) a halogen atom, (2) an OR202 group, or (3) an NR203R204 group;
• R24 represents (1) a hydrogen atom, (2) a C1-4 alkyl group, or (3) a 4- to 10-membered heterocycle,
• R25 and R26 each independently represent (1) a C1-4 alkyl group, or (2) a halogen atom;
• R27 represents (1) a hydrogen atom, (2) a C1-4 alkyl group, or (3) a C3-7 carbon ring;
• R28 and R29 each independently represent (1) a hydrogen atom, (2) a C1-4 alkyl group, or (3) a C3-7 carbon ring;
• R201 represents (1) a hydrogen atom, or (2) a C1-4 alkyl group;
• R202 represents (1) a hydrogen atom, or (2) a C1-4 alkyl group;
• R203 and R204 each independently represents (1) a hydrogen atom, or (2) a C1-4 alkyl group, (3) a C(O)R210 group, or (4) a COOR217 group;
• R205 represents (1) a hydrogen atom, or (2) a C1-4 alkyl group;
• R206 and R207 each independently represent (1) a hydrogen atom, or (2) a C1-4 alkyl group;
• R208 represents (1) a hydrogen atom, (2) a C1-4 alkyl group, (3) a C2-4 alkenyl group, or (4) a C2-4 alkynyl group;
• R210 represents (1) a C1-4 alkyl group optionally substituted with NR211R212 or a cyano group, (2) a C2-4 alkenyl group optionally substituted with NR213R214 or a cyano group, or (3) a C2-4 alkynyl group optionally substituted with NR215R216 or a cyano group;
• R211, R212, R213, R214, R215, R216 and R217 each independently represent (1) a hydrogen atom, or (2) a C1-4 alkyl group;
• R31 represents (1) a hydrogen atom, (2) a C1-4 alkyl group, or (3) a C1-4 haloalkyl group;
• R41 represents (1) a hydrogen atom, (2) a C1-8 alkyl group substituted with one to two substituents selected from the group consisting of (a) a 5- to 7-membered cyclic group optionally substituted with one to two substituents selected from the group consisting of (i) a C1-4 alkyl group, (ii) a C1-4 haloalkyl group, and (iii) a halogen atom, (b) NR401R402, (c) a hydroxyl group, and (d) an SO2R403 group, (3) a C2-8 alkenyl group substituted with one to two substituents selected from the group consisting of (a) a 5- to 7-membered cyclic group optionally substituted with one to two substituents selected from the group consisting of (i) a C1-4 alkyl group, (ii) a C1-4 haloalkyl group, and (iii) a halogen atom, (b) NR401R402, (c) a hydroxyl group, and (d) an SO2R403 group, or (4) a C2-8 alkynyl group substituted with one to two substituents selected from the group consisting of (a) a 5- to 7-membered cyclic group optionally substituted with one to two substituents selected from the group consisting of (i) a C1-4 alkyl group, (ii) a C1-4 haloalkyl group, and (iii) a halogen atom, (b) NR401R402, (c) a hydroxyl group, and (d) an SO2R403 group;
• R401 and R402 each independently represent (1) a hydrogen atom, or (2) a C1-4 alkyl group;
• R403 represents (1) a hydrogen atom, or (2) a C1-4 alkyl group;
• A represents (1) CH, or (2) a nitrogen atom;
• L represents (1) —O—, (2) —NH—, (3) —C(O)—, (4) —CR6R7—, (5) —S—, (6) —S(O)—, or (7) —S(O)2—;
• R6 and R7 each independently represent (1) a hydrogen atom, (2) a halogen atom, (3) a C1-4 alkyl group, (4) a hydroxyl group, or (5) NH2;
• ring1 represents a 5- to 7-membered cyclic group;
• R11, R12, R13, R20, R21, R22, R23, R25, or R26, when being a plurality of groups, may be the same as or different from each other;
• m represents an integer of 0 to 3;
• n represents an integer of 0 to 3;
• q represents an integer of 0 to 4;
• when m is two or more, a plurality of R2 may be the same as or different from each other;
• when n is two or more, a plurality of R3 may be the same as or different from each other;
• when q is two or more, a plurality of R4 may be the same as or different from each other,
• a salt thereof, a solvate thereof, an N-oxide thereof, or a prodrug thereof.