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US 10,208,032 B2Granted
Benzamide and nicotinamide compounds and methods of using same
AssigneeOncotartis Inc.
InventorsAlexander Polinsky, Lioubov Korotchkina, Slavoljub Vujcic, Olga Chernova
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Abstract
The present disclosure provides benzamide and nicotinamide compounds and pharmaceutical uses of the compounds. The compounds can be used to treat, for example, cancers such hematopoietic cancers (e.g., leukemia). The preferred compounds of the invention contain a phenylethynyl moiety as well as an amine-based heterocyclyl or heteroaryl moiety attached to the benzamide or nicotinamide compound.
Claims12
A compound having the following structure:
- wherein X is a carbon atom or nitrogen atom, R1 is selected from the group consisting of a substituted or unsubstituted five to eight membered heterocyclic ring and a five or six membered heteroaryl ring;
- R2 is a substituted or unsubstituted phenyl ring;
- and R3 is a substituted or unsubstituted C2 to C8 alkylheteroaryl group.
Dependencies are inferred from the claim text.