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US 10,208,030 B2Granted
GPR119 agonist compounds
AssigneeMankind Pharma Ltd.
InventorsRakesh Ishwar Patil, Jeevan Verma, Puneet Kumar, Amol Pandurang Gunjal, Himanshu Rai, Santosh Kumar Rai, Anil Kumar
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Abstract
The present invention relates to novel compounds of formula (I), process for preparation of the same and composition comprising these compounds.
Claims26
A compound of the formula (I):
- wherein,
- X1, X2, X3, X4 and X5 are each independently N, O, S or CH;
- and
- X4 and X5 combine to form a five membered ring comprising one or more of heteroatoms each independently selected from N, O and S and the additional five membered ring may be further optionally substituted with one or more of the group selected from F, Cl, Br, I, CF3 and C1-6 alkyl;
- wherein “” is a single or a double bond
- R1 and R2 is independently selected from the group comprising —H, —O, C1-6 alkyl, C1-6alkoxy, —(CH2)n, amino, —CO, —CONH, —NH(Alkyl), —N(Alkyl)2, —NH-aralkyl, —CH2O, —OCH(CH3), halogen, COOR3, —CONR3R4, and NR3COR4;
- R3 and R4 is independently selected from the group comprising hydrogen and C1-6 straight chain or branched chain alkyl which may be further substituted with halogen or C1-6 alkyl;
- n is 0, 1, 2 or 3;
- A is selected from
- B is selected from
- and pharmaceutically acceptable salts, hydrates and stereoisomers thereof.
8 more elements
Dependencies are inferred from the claim text.