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US 10,208,021 B2Granted
Substituted tetrahydroisoquinoline compounds as factor XIa inhibitors
AssigneeBristol-Myers Squibb Company
InventorsMichael J. Orwat, Donald J. P. Pinto, Leon M. Smith, II, Shefali Srivastava
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Abstract
The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.
Claims3
A method of treating a thromboembolic or an inflammatory disorder, comprising administering to a patient in need thereof a therapeutically effective amount of a compound of the structure
- or a pharmaceutically acceptable salt or solvate form thereof.
Dependencies are inferred from the claim text.