Use of strigolactones and strigolactone analogs for treating proliferative conditions
OwnerYoram Kapulnik, Hinanit Koltai +2inventors
InventorsYoram Kapulnik, Hinanit Koltai, Ronit Yarden, Cristina Prandi
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Abstract
Compound of formula X wherein P1 is a fused-ring system comprising one 6-membered and two 5-membered rings; v indicates an S or R configuration; or individual isomers or pharmaceutically acceptable salts thereof, or mixtures thereof, in the preparation of an active agent for preventing or inhibiting cell proliferation or for inducing cell death.
Claims4
A method for inhibiting the proliferation of a cancerous cell in a patient in need thereof, or for inducing death of a cancerous cell in a patient in need thereof, wherein said cancerous cell comes from cancer selected from the group consisting of breast cancer, lung cancer, prostate cancer, colon cancer, leukemia and osteosarcoma, said method comprising the step of administering to said patient an effective amount of a compound of formula III
- or its stereoisomer or pharmaceutically acceptable salt thereof;
- wherein R1 is C1-C6 alkyl;
- Z is CH, and Y is N;
- R6 is H or C1-C6 alkyl;
- R2 and R5 represent H;
- and
- one of R3 and R4 represents H whereas the other is selected from the group consisting of H, Halogen, C1-C6 alkyl, heterocyclyl, cycloalkyl, benzcycloalkyl, thienyl, 2,3-dihydrothieno[3,4-b][1,4]dioxin-7-yl, and phenyl or naphthyl substituted with nitro, dialkylamino or methoxy group.
Dependencies are inferred from the claim text.