PKM2 modulators and methods for their use

A compound having the following structure (I):

• or a stereoisomer, pharmaceutically acceptable salt, tautomer or prodrug thereof,
• wherein:
• R1 is haloalkyl, halo, nitrile or amino;
• R2 is H or halo;
• R3 is alkyl, alkoxyalkyl, cycloalkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl or aralkyl;
• R4 has one of the following structures:
• R5 and R6 are each independently H or alkyl;
• R7 and R8 are each independently H, alkyl, alkoxy, halo, hydroxyl, hydroxylalkyl, amino, aminoalkyl, alkylaminoalkyl, nitrile, nitro, —O(CH2)mP(═O)(OH)2 or amino acid ester;
• and
• m is 0 or 1,
• wherein each occurrence of cycloalkyl, haloalkyl, alkyl, alkoxyalkyl, cycloalkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, aralkyl and aryl is optionally substituted.