Methods and compositions for treatment of cancer and autoimmune disease
AssigneeThe Jackson Laboratory
InventorsKevin David Mills, Muneer Gulamhusien Hasham, Caroline Gardner McPhee
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Abstract
The technology described herein relates to methods of inducing cell death. The technology described herein further relates to treating conditions including cancers and autoimmune diseases comprising administering inhibitors of double strand break repair. Also described herein are inhibitors of double strand break repair and methods of screening for such inhibitors.
Claims1
A method of reducing viability of a cancerous B cell, a chronic lymphoblastic leukemia (CLL) cell, or a B-cell lymphoma/leukemia cell, wherein the cell is determined to have a detectable level of activation-induced cytidine deaminase (AID), the method comprising;
- contacting the cell with an inhibitor of DNA double strand break repair, and
- wherein the inhibitor of DNA double strand break repair is selected from the group consisting of:
- (E)-4,4′-(ethene-1,2-diyl)bis(N-methylbenzamide);
- (E)-N-(4-(4-(dimethylamino)styryl)phenyl)cyclopropanesulfonamide;
- (E)-N-(4-(4-(dimethylamino)styryl)phenyl)propane-2-sulfonamide;
- (E)-N,N′-(ethene-1,2-diylbis(4,1-phenylene))bis(propane-2-sulfonamide);
- (E)-N,N′-(ethene-1,2-diylbis(4,1-phenylene))bis(dimethylamino-sulfonamide);
- sodium 6,6′-(ethane-1,2-diyl)bis(3-(3-isopropylureido)benzenesulfonate);
- sodium (E)-5-(3-cyclopropylthioureido)-2-(4-(1-methylethylsulfonamido)-2-sulfonatostyryl)benzenesulfonate;
- sodium (E)-5-(3-ethylureido)-2-(4-(2-methoxyacetamido)-2-sulfonatostyryl)benzenesulfonate;
- sodium (E)-5-acetamido-2-(4-(cyclopropanesulfonamido)-2-sulfonatostyryl)benzenesulfonate;
- and
- sodium (E)-5-acetamido-2-(4-((N,N-dimethylsulfamoyl)amino)-2-sulfonatostyryl)benzenesulfonate.
Dependencies are inferred from the claim text.