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US 10,207,986 B2Granted
Method for preparing D-arginine
AssigneeAminiologics Co., Ltd.
InventorsIl-Suk Byun, Won-Sup Kim, Hye-Lim Ga, Jung-Ho Lee
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Abstract
Disclosed is a method of preparing D-arginine, wherein D-arginine is obtained by the optical resolution of DL-arginine using D-3-bromocamphor-10-sulfonic acid as an optical resolving agent.
Claims3
A method of preparing D-arginine, comprising steps of:
- (1) removing L-arginine and a D-3-bromocamphor-10-sulfonic acid salt, deposited by the optical resolution of DL-arginine using D-3-bromocamphor-10-sulfonic acid;
- and
- (2) purifying D-arginine left behind in a filtrate from which deposits are removed,
- wherein the D-3-bromocamphor-10-sulfonic acid is at least one selected from the group consisting of a D-3-bromocamphor-10-sulfonic acid hydrate and a D-3-bromocamphor-10-sulfonic acid ammonium salt,
- wherein the removing L-arginine and a D-3-bromocamphor-10-sulfonic acid salt further comprises adding the DL-arginine and the D-3-bromocamphor-10-sulfonic acid to a solvent comprising methanol, and
- wherein the solvent does not comprise isobutyl alcohol, chloroform, or toluene.
3 more elements
Dependencies are inferred from the claim text.