Solid forms of desvenlafaxine
AssigneeAlparis, S.A. De C.V.
InventorsJorge Guillermo Domínguez Chávez, Karina Mondragón Vásquez, Hugo Morales Rojas, Dea Herrera Ruiz, Herbert Höpfl, Reyna Reyes Martínez, Javier Hernández Illescas, Juan Pablo Senosiain Peláez
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Abstract
The present invention refers to new amorphous and crystalline solid forms of desvenlafaxine, also known as O-desmethylvenlafaxine or desmethylvenlafaxine, and to its salts, solvates, hydrates and polymorphs thereof, as well as to their use in the manufacture of a pharmaceutical composition useful in the treatment of depression and/or as a selective serotonin and norepinephrine reuptake inhibitor and also in menopause-associated vasomotor disorders.
Claims5
An amorphous solid compound formed by desvenlafaxine and a co-former X, wherein X is selected from the group consisting of 3-hydroxybenzoic acid, 3,4-dihydroxybenzoic acid, and 3,4,5-trihydroxybenzoic acid;
- or any solvate or hydrate of the amorphous solid compound.
A crystalline solid compound formed by desvenlafaxine and a co-former X, wherein X is selected from the group consisting of 2,4-dihydroxybenzoic acid and 3,4-dihydroxybenzoic acid, or any solvate or hydrate of the crystalline solid compound.
Dependencies are inferred from the claim text.