US 10,207,030 B2Granted

Implantable devices for bone or joint defects

AssigneeUniversity of Utah Research Foundation

InventorsAmanda Elaine Brooks, David W. Grainger, Kristofer D. Sinclair, Benjamin Delbert Brooks

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Abstract

In one aspect, the invention provides an implantable device comprising a uniform mixture of components including degradable polymer, inorganic bone particulate either natural or synthetic, a drug, and a soluble microporagen. In some embodiments, the uniform mixture further includes a soluble polymer macroporagen. In some embodiments, the uniform mixture is coated with an immobilized outer porous layer comprising or consisting of synthetic or natural inorganic bone granules. In further aspects, the invention provides an implantable device comprising a composite core of degradable polymer, bone, and a drug, and a coating comprising or consisting of microporous bone overlayer covering the degradable composite core.

Claims14

Dependent claims

An implantable device comprising a uniform mixture of components including:

a degradable polymer,
bone,
a drug,
a macroporagen including polyethylene glycol, and
a microporagen selected from the group consisting of a salt of an alkali metal, a salt of an alkaline earth metal, and combinations thereof;
wherein:
(a) the amount of bone by weight exceeds the combined weight of all the other components,
(b) the amount of degradable polymer is less than 30% by weight of the device;
(c) the components are selected and provided in relative amounts such that following implantation:
(i) water molecules dissolve the microporagen to create micropores in the device,
(ii) the water molecules enter the resulting micropores,
(iii) the entering water molecules dissolve or degrade the macroporagen and the degradable polymer,
(iv) the drug is released while creating sufficient space for cell migration into the device and while retaining structural integrity of the device long enough to serve as a scaffold to establish osteoconduction, and
(d) the degradable polymer has a degree of crystallinity and molecular weight selected to cause the degradable polymer to degrade in a manner to render the device resorbable and able to release the drug over a time period of at least six weeks following implantation.

11 more elements

Dependencies are inferred from the claim text.

Facts

Application: 15/868,625Filed 11 Jan 2018 · continuation
Priority: 5 Feb 2013
Published: US 2018/0133374 A117 May 2018
Granted: 19 Feb 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification22 codes

A61L 27/58
Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface…:…
A61K 31/7036
Attached to a carbocyclic compound, e.g. phloridzin: having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin,…
A61L 27/26
Macromolecular materials: mixtures of macromolecular compounds
A61L 27/306
Inorganic materials: other specific inorganic materials not covered by A61L27/303 - A61L27/32

Family

Application61/761,086Us provisional application · filed 5 Feb 2013
PCT/US2014/014832Parent of this continuation · filed 5 Feb 2014
US 2018/0133374 A1Pre-grant publication · published 17 May 2018
Application14/765,662Parent of this continuation
US 9,889,235 B2Parent of this continuation
US 2016/0129157 A1Published application
US 10,207,030 B2This patent

From the US filing history. Foreign family members aren’t listed.