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US 10,207,023 B2Granted
Antibacterial calcium-based materials
AssigneeNational Cheng Kung University
InventorsJiin-Huey Chern-Lin, Chien-Ping Ju, Chang-Keng Chen, Bing-Chen Yang
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Abstract
A preparation at least useful as a bone implant is provided, which contains a solid component including a lithium compound and a calcium compound. The preparation shows an anti-bacterial ability in comparison with a preparation contains the calcium compound but free of the lithium compound.
Claims16
A bone implant for treating a bony site of a subject, wherein said bone implant is composed of a freestanding block or granules or pieces obtained from said freestanding block;
- and said bone implant consists of a calcium compound and a lithium compound, and optionally one or more components selected from the group consisting of a growth factor, a bone morphogenetic protein (BMP), living cells, a drug and, a poly(acrylic acid), wherein when the poly(acrylic acid) is present it is present in an amount of 0.01-5% based on the total weight of the bone implant, wherein the lithium compound is configured to dissolve from the bone implant in the bony site after the bone implant is implanted in the bony site of the subject to keep bacteria from approaching the bone implant,
- wherein the lithium compound is not lithium halide,
- wherein the calcium compound is selected from the group consisting of tetracalcium phosphate, dicalcium phosphate, hydroxyapatite, calcium sulfate dihydrate, calcium sulfate hemihydrate, and a mixture thereof.
Dependencies are inferred from the claim text.