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US 10,207,013 B2Granted
Gadolinium-based contrast agents for sensitive detection of Zn2+ with MRI
AssigneeBoard of Regents, The University of Texas Systems
InventorsChristian Preihs, Jing Yu, Veronica Clavijo Jordan, Yunkou Wu, Khaled Nasr, A. Dean Sherry, Sara Chirayil
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Abstract
In some aspects, the present disclosure provides novel ligands, which may be used to make novel MRI contrast agents for the detection of zinc. In further aspects, by the present disclosure also provides methods of using as imaging agents and compositions thereof.
Claims19
A compound of the formula:
- wherein:
- A1, A2, A3, and A4 are each independently alkanediyl(C≤12) or substituted alkanediyl(C≤12);
- and
- R1, R2, R3, and R4 are each independently hydroxy, amino, alkylamino(C≤12), substituted alkylamino(C≤12), dialkylamino(C≤12), substituted dialkylamino(C≤12), or
- wherein:
- X1 and X2 are each independently heteroaralkyl(C≤12) or substituted heteroaralkyl(C≤12);
- provided that at least one of A1, A2, A3, or A4 is not —CH2—;
- provided that at least one of R1, R2, R3, and R4 is
- or a metal complex, a deprotonated form, or a salt thereof.
6 more elements
Dependencies are inferred from the claim text.