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US 10,207,010 B2Granted
Compositions and methods for delivery of agents
AssigneeModernaTX, Inc.
InventorsGilles Besin, Stephen Hoge, Joseph Senn, Kerry Benenato, Staci Sabnis
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Abstract
This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.
Claims24
A lipid nanoparticle (LNP) comprising a PEG-lipid, an ionizable lipid that is an ionizable amino lipid, a helper lipid, and a structural lipid,
- wherein the PEG-lipid comprises a compound of Formula (V):
- or a pharmaceutically acceptable salt thereof, wherein:
- R3 is —ORO;
- RO is hydrogen, optionally substituted alkyl or an oxygen protecting group;
- r is an integer between 1 and 100, inclusive;
- and R5 is optionally substituted C10-40 alkyl;
- and
- wherein the ionizable amino lipid has the structure of compound 18:
- or a pharmaceutically acceptable salt thereof.
6 more elements
Dependencies are inferred from the claim text.