Conjugates of tumor necrosis factor inhibitors to functionalized polymers

A conjugate, or a pharmaceutically acceptable salt thereof, comprising a structure of formula (10):

• or a salt form thereof,
• wherein:
• polymer is a linear, water-soluble, non-peptidic, and non-nucleotidic polymer backbone, wherein each linking group is bonded at a different terminus of said polymer;
• E and E1 are independently O or S;
• K and K1 are independently selected from the group consisting of:
• alkylene, alkyleneoxyalkylene, and oligomeric alkyleneoxyalkylene;
• G and G1 are independently absent or are selected from the group consisting of:
• alkoxy and a hydrophobic separation handle;
• each pair of Z1 and Z2 and Z3 and Z4 are independently selected from O and NH, wherein only one of each pair of Z1 and Z2 and Z3 and Z4 can be NH;
• L and L1 are independently selected from the group consisting of:
• a divalent radical of a nucleoside, alkylene, alkyleneoxyalkylene, oligomeric alkyleneoxyalkylene, and unsubstituted and substituted arylene;
• L2 is a covalent linking moiety between L on the polymer backbone and B;
• L3 is a covalent linking moiety between L on the polymer backbone and B1;
• and
• B and B1 are independently a TNF inhibitor, a derivative of a TNF inhibitor, a biologic other than a TNF inhibitor, a drug, a detectable group, a separation moiety, wherein at least one of B and B1 is a TNF inhibitor or a derivative of a TNF inhibitor.