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US 10,206,990 B2Granted
Cytotoxic T lymphocyte inducing immunogens for prevention treatment and diagnosis of cancer
AssigneeImmunotope, Inc.
InventorRamila Philip
Life of this patent
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Abstract
The present invention relates to compositions and methods for the prevention, treatment, and diagnosis of cancer, especially carcinomas, such as pancreatic carcinoma. The invention discloses peptides, polypeptides, and polynucleotides that can be used to stimulate a CTL response against pancreatic and other cancers.
Claims8
A method for treating tumor cells in a subject comprising:
- (a) eliciting a CTL response against tumor cells presenting at least one epitopic peptide from a group of peptides consisting of SEQ ID NOS:
- 1 through 3 and SEQ ID NOS:
- 5 through 53 by administration of a sufficient amount of a composition containing at least one peptide from the group and a stabilizing agent;
- or
- (b) stimulating an immune response in an immunologically competent animal, said composition consisting of at least one of SEQ ID NOS:
- 1 through 3 and SEQ ID NOS:
- 5 through 53 and a stabilizing agent capable of facilitating an immune response thereof.
4 more elements
A method for treating tumor cells in a subject comprising:
- (a) eliciting a CTL response against tumor cells presenting at least one epitopic peptide from a group of peptides consisting of SEQ ID NOS:
- 1 through 3 and SEQ ID NOS:
- 5 through 53 by administration of a sufficient amount of a composition containing at least one peptide from the group linked through a non-conventional peptide bond to an additional peptide sequence and a stabilizing agent;
- or
- (b) stimulating an immune response in an immunologically competent animal, said composition consisting of at least one of SEQ ID NOS:
- 1 through 3 and SEQ ID NOS:
- 5 through 53 and a stabilizing agent capable of facilitating an immune response thereof.
4 more elements
Dependencies are inferred from the claim text.